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This review examines the contribution of OCSCs and associated signaling pathways to tumor dynamics in ovarian cancer.

June 2, 2026Open Access

Regulatory Signaling Pathways in Ovarian Cancer Stem Cells: Their Role in Tumor Progression and Therapeutic Strategies

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This review examines the contribution of OCSCs and associated signaling pathways to tumor dynamics in ovarian cancer.
Summarized roles of Wnt/β-catenin, Notch, and Hedgehog pathways in OCSCs.
Evaluated therapeutic agents targeting these pathways, including various inhibitors.
Explored implications for combination treatment strategies and personalized approaches.
Signaling pathways synergize to enhance OCSC capabilities, contributing to tumor progression.
Monotherapies show limited success due to compensatory interactions among pathways.
Combination treatment strategies may improve therapeutic outcomes in ovarian cancer.

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Review summarizes the role of signaling pathways in tumor progression among ovarian cancer stem cells, suggesting the need for combination therapies.

Amalia et al. (2025) studied this question.

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Review summarizes the role of signaling pathways in tumor progression among ovarian cancer stem cells, suggesting the need for combination therapies.