A Case of Gangrenous Cholecystitis during Tocilizumab Therapy Successfully Treated with Early Surgical Intervention

Q: What does this research mean for the field?

Tocilizumab therapy can mask systemic inflammatory signs in patients with severe infections such as gangrenous cholecystitis, necessitating early surgical intervention based on imaging and clinical symptoms rather than laboratory markers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Shinichiro Ogawa; Tomohiko ADACHI; Hajime IMAMURA; Hajime Matsushima; Akihiko SOYAMA; Susumu EGUCHI

doi:10.3919/jjsa.86.1471

January 1, 2025Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)Open Access

A Case of Gangrenous Cholecystitis during Tocilizumab Therapy Successfully Treated with Early Surgical Intervention

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Key Points

To report a case of gangrenous cholecystitis occurring during tocilizumab therapy and emphasize early surgical intervention's importance.
Case report of a 64-year-old male with TAFRO syndrome receiving tocilizumab.
Diagnostic imaging identified acute cholecystitis, leading to emergency laparoscopic cholecystectomy.
Pathological examination confirmed the diagnosis of gangrenous cholecystitis.
Emergency laparoscopic cholecystectomy revealed gangrenous changes in the gallbladder wall.
Pathological findings confirmed the diagnosis of gangrenous cholecystitis.
Early surgical intervention was deemed necessary due to masked inflammatory signs during tocilizumab treatment.

Implication

Case report shows successful surgical intervention for gangrenous cholecystitis during tocilizumab therapy, indicating timely treatment is crucial.

Abstract

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Cite This Study

Ogawa et al. (2025) studied this question.

synapsesocial.com/papers/6a1e726230b38c64201b5a68 https://doi.org/10.3919/jjsa.86.1471

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A Case of Gangrenous Cholecystitis during Tocilizumab Therapy Successfully Treated with Early Surgical Intervention

Key Points

Implication

Abstract

Discussion

Cite This Study

A Case of Gangrenous Cholecystitis during Tocilizumab Therapy Successfully Treated with Early Surgical Intervention

Key Points

Implication

Abstract

Discussion

Cite This Study

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