What does this research mean for the field?

Lower cerebrovascular reactivity (CVR), measured specifically through cerebral blood flow changes using arterial spin labeling (ASL) MRI, is significantly associated with poorer cognitive performance, whereas baseline resting cerebral blood flow is not. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 31, 2021Frontiers in PhysiologyOpen Access

Relationship Between Cerebrovascular Reactivity and Cognition Among People With Risk of Cognitive Decline

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Why the study?

BOLD MRI measures of cerebrovascular reactivity (CVR) reflect multiple physiological parameters, leaving the relationship between arterial spin labeling-measured cerebral blood flow or CVR and cognitive performance to be clarified.

Is cerebrovascular reactivity measured by ASL MRI during hypercapnia associated with cognitive performance in people at risk of cognitive decline?

Comparison

Baseline resting CBF vs hypercapnia-induced CVR

Design

Cross-sectional study

Authors

DKDong‐Hoon KimKangbuk Samsung Hospital THTimothy M. HughesVascular Medicine MLMegan E. LipfordAtrium Health Wake Forest Baptist

Discussion

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Implication

CVR by ASL MRI was associated with MMSE scores in at-risk adults; leaves open its role as a vascular biomarker pending longitudinal studies.

Structured PICO

Is cerebrovascular reactivity measured by ASL MRI during hypercapnia associated with cognitive performance in people at risk of cognitive decline?

Population

78 participants with risk of cognitive decline

Intervention

Measurement of cerebrovascular reactivity (CVR) using dynamic arterial spin labeling (ASL) MRI during a hypercapnia challenge (targeting 10 mmHg higher end-tidal CO2 level than baseline)

Outcome

Relationship between cerebral blood flow (CBF) or CVR and cognitive performance measured by the Mini-mental state examination (MMSE) scoresurrogate

Cerebrovascular reactivity measured by ASL MRI during hypercapnia is associated with cognitive performance, suggesting its potential as a biomarker for vascular dysfunction leading to cognitive decline.

Cite This Study

Kim et al. (2021) studied this question.

synapsesocial.com/papers/6a1e739960864841a668e9da https://doi.org/10.3389/fphys.2021.645342

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Implication

CVR by ASL MRI was associated with MMSE scores in at-risk adults; leaves open its role as a vascular biomarker pending longitudinal studies.

Relationship Between Cerebrovascular Reactivity and Cognition Among People With Risk of Cognitive Decline

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship Between Cerebrovascular Reactivity and Cognition Among People With Risk of Cognitive Decline

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider