Ileal bile acid transporter inhibitors for chronic constipation in the elderly

for their valuable study on the efficacy of elobixibat in elderly patients with chronic constipation (CC). This study provides valuable insights into the safety and efficacy of elobixibat in elderly patients with CC. We have a few critical points regarding the study methodology and evaluation of CC in the elderly population. The authors have not commented on the exclusion of possible drug-related constipation, as most of their elderly patients have comorbid illness, structural causes of constipation, evaluation of gastrointestinal motility, and advocating for a more comprehensive workup for CC in the elderly. This article also provides a comprehensive review of the workup of CC in the elderly, as well as a review of the available evidence on ileal bile acid transporter inhibitor - elobixibat in CC.