Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle
Population
Skeletal C2C12 myoblasts in culture and muscle tissue-types (skeletal muscle, diaphragm, and heart)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports caveolin-3 investigation in cardiac muscle; leaves open human disease relevance pending further validation.
Structured PICO
P
Population
Skeletal C2C12 myoblasts in culture and muscle tissue-types (skeletal muscle, diaphragm, and heart)
I
Intervention
Molecular cloning and expression of caveolin-3
O
Outcome
Identification, sequence homology, tissue expression pattern, and functional characteristics of caveolin-3
The identification of caveolin-3, a muscle-specific member of the caveolin gene family, provides a basis for understanding the role of caveolae in cardiac, smooth, and skeletal muscle cells.
Cite This Study
Tang et al. (1996) studied this question.