Long-term methylphenidate exposure and 24-hours blood pressure and left ventricular mass in adolescents and young adults with attention deficit hyperactivity disorder
Why the study?
Does long-term methylphenidate exposure increase 24-hour blood pressure, heart rate, and left ventricular mass in adolescents and young adults with ADHD?
Population
Adolescents and young adults with ADHD
Comparison
Long-term MPH treated group vs MPH-naïve group
Authors
Discussion
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Member takes
Implication
Daytime BP/HR increases with methylphenidate may warrant monitoring in ADHD youth; leaves open long-term cardiovascular risk.
Structured PICO
Does long-term methylphenidate exposure increase 24-hour blood pressure, heart rate, and left ventricular mass in adolescents and young adults with ADHD?
P
Population
Adolescents and young adults with attention deficit hyperactivity disorder (ADHD)
I
Intervention
Long-term methylphenidate (MPH) treatment
C
Comparator
MPH-naïve individuals with ADHD (unmedicated)
O
Outcome
24-hour blood pressure (systolic and diastolic), heart rate, and left ventricular mass corrected for body-surface area (LVMBSA)surrogate
Long-term methylphenidate use in adolescents and young adults with ADHD is associated with small daytime increases in systolic blood pressure and heart rate, but does not significantly affect left ventricular mass.
Limitations
- Small sample size
- Need for longer treatment duration
- Lack of within-subject design
Cite This Study
Buitelaar et al. (2022) studied this question.