Why the study?
Does SC-54701A alone or in combination with aspirin and heparin increase time to occlusion in a canine model of coronary artery thrombosis?
Population
66 dogs in a canine model of continuous current injury (coronary artery thrombosis)
Comparison
SC-54701A at various doses alone or in… vs Saline or monotherapy with aspirin or heparin
Design
Preclinical
Follow-up
180 minutes
Authors
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Supports adjunctive GPIIb/IIIa antagonism with ASA/heparin in thrombosis models; hypothesis-generating and requires human trials before clinical adoption.
Does SC-54701A alone or in combination with aspirin and heparin increase time to occlusion in a canine model of coronary artery thrombosis?
A lower dose of the GPIIb/IIIa antagonist SC-54701A combined with aspirin and heparin maximizes antithrombotic efficacy in a canine model of coronary thrombosis.
Frederick et al. (1996) studied this question.
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