Why the study?
The study was conducted to evaluate the effect of risk factors on over-anticoagulation in patients taking vitamin K antagonists.
What risk factors are associated with increased bleeding in patients with over-anticoagulation from vitamin K antagonists?
Population
79 patients taking VKAs with an INR above the indicated anticoagulation dose
Comparison
Assessment of risk factors for bleeding and over-anticoagulation
Design
Cross-sectional descriptive, prospective research
Authors
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Coenzyme Q10 and cruciferous vegetable use was associated with higher bleeding risk on vitamin K antagonists; this cross-sectional observation is hypothesis-generating and needs prospective validation.
What risk factors are associated with increased bleeding in patients with over-anticoagulation from vitamin K antagonists?
In patients over-anticoagulated with vitamin K antagonists, consumption of coenzyme Q10 and cruciferous vegetables is associated with a significantly increased risk of bleeding.
Chu et al. (2023) studied this question.
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