Why the study?
Does insufficient VKA therapy increase stroke severity and proximal artery occlusion in patients with AF and acute anterior-circulation stroke compared to no anticoagulation?
Does insufficient VKA therapy increase stroke severity and proximal artery occlusion in patients with AF and acute anterior-circulation stroke compared to no anticoagulation?
In patients with atrial fibrillation and acute anterior-circulation stroke, subtherapeutic VKA therapy on admission is paradoxically associated with more severe strokes and proximal occlusions than receiving no anticoagulation.
No takes yet. Share an insight, caveat, or question.
Subtherapeutic VKA may worsen stroke severity versus none in AF; hypothesis-generating and should not change practice.
Sakamoto et al. (2017) studied this question.
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