What does this research mean for the field?

Calcineurin acts as a critical upstream regulator of pressure-overload cardiac hypertrophy, and its pharmacological inhibition with cyclosporine A can attenuate and partially reverse this hypertrophic response. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 23, 2000Circulation

Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy

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Why the study?

Does cyclosporine A administration attenuate load-induced cardiac hypertrophy in rats with pressure-overload?

Structured PICO

Does cyclosporine A administration attenuate load-induced cardiac hypertrophy in rats with pressure-overload?

Population

Rats with pressure-overload hypertrophy induced by abdominal aortic banding

Intervention

Cyclosporine A (CsA) administration over a 14-day treatment protocol

Outcome

Cardiac hypertrophy (histological and molecular indexes) and calcineurin enzymatic activity/protein contentsurrogate

Calcineurin inhibition with cyclosporine A attenuates and partially reverses pressure-overload cardiac hypertrophy in a rat model, suggesting calcineurin is a key upstream regulator.

Discussion

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Implication

Supports calcineurin inhibition in rodent pressure-overload models; leaves open translation to human hypertrophy or HF.

Cite This Study

Lim et al. (2000) studied this question.

synapsesocial.com/papers/6a1e7cd338ac63281c952693 https://doi.org/10.1161/01.cir.101.20.2431

Topics

Hypertension management

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Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy

Structured PICO

Discussion

Implication

Cite This Study

Topics

Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider