In a rat model of pressure overload-induced left ventricular hypertrophy, myofibrillar mass increases disproportionately to total cell volume, while relative mitochondrial volume decreases.
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Hypothesis-generating for myofibrillar-mitochondrial imbalance in pressure-overload LVH; leaves open relevance to human HF energetics and progression.
Page et al. (1972) studied this question.
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