What does this research mean for the field?

An increase in RNA polymerase activity is one of the earliest biochemical events in the myocardium during the development of pressure overload-induced cardiac hypertrophy, detectable within 12 hours of aortic banding. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1968Circulation ResearchOpen Access

Biochemical Correlates of Cardiac Hypertrophy

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Population

mature rats

Comparison

supravalvular aortic stenosis produced with a… vs sham-operated controls

Design

Preclinical

Follow-up

2 weeks

Authors

KNK. G. NairWilliams & Associates ACAnthony F CutillettaRush University Medical Center RZRadovan ZakUniversity of Chicago

Discussion

Member takes

Implication

Early RNA polymerase activation may initiate hypertrophy in pressure-overload models; leaves open translation to human mechanisms or therapies.

Structured PICO

Population

mature rats

Intervention

supravalvular aortic stenosis produced with a specially designed silver clip (aortic banding)

Comparator

sham-operated controls

Outcome

RNA polymerase activity, heart weight, body weight, and RNA content of the myocardiumsurrogate

An increase in RNA polymerase activity is one of the earliest biochemical events in the myocardium following aortic banding-induced cardiac hypertrophy.

Cite This Study

Nair et al. (1968) studied this question.

synapsesocial.com/papers/6a169d272fcf950e0005100e https://doi.org/10.1161/01.res.23.3.451

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Implication

Early RNA polymerase activation may initiate hypertrophy in pressure-overload models; leaves open translation to human mechanisms or therapies.