Experimental cardiac hypertrophy induced by hemodynamic load increases RNA concentration in the affected ventricle, suggesting a fundamental growth response.
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Early animal data link load to ventricular RNA increases; leaves open translation to human hypertrophy mechanisms.
Banding of the aorta or pulmonary artery in puppies produces a selectively increased concentration of RNA in the ventricle with the increased hemodynamic load as compared to the opposite side or to normal hearts. The increase in concentration of RNA following distortion of the myocardial cell may represent a fundamental response of growth and the system described mayserve as a useful model for its study.
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Gluck et al. (1964) studied this question.
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