Key result
Extracts from hypertrophying dog hearts increased the synthesis of messenger RNA and initiated hypertrophy when perfused through isolated rat hearts, demonstrating they are not species-specific.
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Molecules initiating cardiac hypertrophy are not species-specific, as extracts from hypertrophying dog hearts can stimulate mRNA transcription and hypertrophy in isolated rat hearts.
Extracts from hypertrophying dog hearts perfused through isolated rat hearts increase the synthesis of messenger RNA and initiate hypertrophy in the treated hearts. Total RNA extracted from experimental and control hearts was translated in vitro and hybridized with polyuridylate. Synthesis of protein and polyadenylate-containing RNA was greater in rat hearts perfused with extracts of hypertrophying dog hearts than in control hearts. The results demonstrate that molecules from hypertrophying dog hearts are not species-specific since they are effective in stimulating transcription of messenger RNA in rat hearts as well as in dog hearts.
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Hammond et al. (1982) studied Cardiac hypertrophy. Extracts from hypertrophying dog hearts vs. Control hearts was evaluated on Synthesis of messenger RNA and initiation of hypertrophy. Extracts from hypertrophying dog hearts increased the synthesis of messenger RNA and initiated hypertrophy when perfused through isolated rat hearts, demonstrating they are not species-specific.
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