Key result
Pressure-overload hypertrophy in the developing rabbit heart reveals activation of divergent gene and protein pathways, with LV-AOB dominated by mitochondrial function and RV-PAB by both mitochondrial function and cardiac muscle tissue development.
Why the study?
Does pressure-overload hypertrophy via LV-AOB or RV-PAB induce divergent gene and protein pathways in the immature heart of newborn rabbits?
Does pressure-overload hypertrophy via LV-AOB or RV-PAB induce divergent gene and protein pathways in the immature heart of newborn rabbits?
Pressure-overload hypertrophy induces divergent transcript and protein expression profiles in the left versus right ventricular myocardium of the developing heart.
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Chamber-specific responses in neonatal pressure overload warrant caution in extrapolating to infants; leaves open targeted pathway validation in translational models.
Friehs et al. (2012) studied Pressure-overload hypertrophy (n=24). Aortic banding (LV-AOB) and Pulmonary artery banding (RV-PAB) vs. Sham-operated controls was evaluated on Transcript and protein expression profiles. Pressure-overload hypertrophy in the developing rabbit heart reveals activation of divergent gene and protein pathways, with LV-AOB dominated by mitochondrial function and RV-PAB by both mitochondrial function and cardiac muscle tissue development.
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