Why the study?
Pulmonary hypertension causes RV pressure overload, but research has focused on the RV while overlooking the LV, which mechanically assists RV contraction.
Does right ventricular pressure overload induced by pulmonary arterial banding cause biomechanical and gene expression changes in the left ventricle in mice?
Population
Nine male mice
Comparison
Pulmonary arterial banding (N = 4) vs sham surgery (N = 5)
Design
Animal experimental study
Follow-up
7 weeks
Key result
Pulmonary arterial banding in mice significantly decreased LV and RV ejection fraction and LV torsion, and increased LV perivascular fibrosis and altered gene expression.
Authors
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LV changes in RV overload model merit human validation; leaves open biventricular therapeutic targets in PH.
Does right ventricular pressure overload induced by pulmonary arterial banding cause biomechanical and gene expression changes in the left ventricle in mice?
Right ventricular pressure overload induces significant biomechanical and transcriptional changes in the left ventricle, highlighting the LV as a potential therapeutic target in pulmonary hypertension.
Kheyfets et al. (2020) studied Right ventricular pressure overload (n=9). Pulmonary arterial banding (PAB) vs. Sham surgery was evaluated on Biomechanical and gene expression changes in the left ventricle. Pulmonary arterial banding in mice significantly decreased LV and RV ejection fraction and LV torsion, and increased LV perivascular fibrosis and altered gene expression.
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