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March 1, 2017Physiological ReportsOpen Access

Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle

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Population

Murine model of pressure overload-induced right ventricular (RV) hypertrophy in C57Bl/6J mice

Design

Preclinical

Follow-up

21 days

Authors

HLHimal LuitelAgriculture and Forestry UniversityASAkylbek SydykovJustus-Liebig-Universität GießenYSYves SchymuraEli Lilly (United States)

Discussion

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Overview

Mast cell accumulation may contribute to RV remodeling; leaves open whether targeting them could treat RV failure in humans.

Structured PICO

P
Population
Murine model of pressure overload-induced right ventricular (RV) hypertrophy in C57Bl/6J mice
I
Intervention
Pulmonary artery banding (PAB) to induce pressure overload
O
Outcome
Time course of structural and functional changes in the right ventricle assessed by magnetic resonance imagingsurrogate

Pressure overload-induced right ventricular remodeling is associated with the accumulation and activation of mast cells, suggesting they may represent a novel therapeutic target for RV failure.

Cite This Study

Luitel et al. (2017) studied this question.

synapsesocial.com/papers/69d0005fc654f7f259e76e23https://doi.org/10.14814/phy2.13146
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Responses of the Right Ventricle to Abnormal Loading Conditions in Mice: Pressure vs. Volume Load2011 · 83 citations
  2. 2Long-term pressure-induced cardiac hypertrophy: capillary and mast cell proliferation1989 · 62 citations
  3. 3Distinct loading conditions reveal various patterns of right ventricular adaptation2013 · 64 citations
  4. 4Molecular and physiological alterations in murine ventricular dysfunction.1994 · 163 citations
  5. 5Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State2007 · 386 citations