Population
Rats undergoing pulmonary artery banding (PAB) surgery
Design
Preclinical
Follow-up
3 weeks
Key result
Mild pulmonary artery constriction in rats resulted in adaptive RV hypertrophy with preserved function, whereas severe constriction caused maladaptive hypertrophy and dysfunction at 3 weeks.
Authors
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Severity-dependent RV remodeling in rat models warrants cautious interpretation; leaves open mechanisms and human translation of adaptive hypertrophy.
This study establishes a reliable, short-duration rat model of pulmonary artery banding that distinguishes between adaptive and maladaptive right ventricular remodeling based on the severity of constriction.
Mendes‐Ferreira et al. (2016) studied Right ventricle remodeling / Pulmonary arterial hypertension. Pulmonary artery banding (mild vs severe constriction) was evaluated on Right ventricle remodeling and function. Mild pulmonary artery constriction in rats resulted in adaptive RV hypertrophy with preserved function, whereas severe constriction caused maladaptive hypertrophy and dysfunction at 3 weeks.