June 1, 2013AJP Heart and Circulatory Physiology
Distinct loading conditions reveal various patterns of right ventricular adaptation
Key result
Different types of right ventricular loading resulted in distinct patterns of RV adaptation, with pulmonary artery banding causing the strongest contractility enhancement and diastolic dysfunction.
Authors
Discussion
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Overview
Unique RV adaptation patterns by loading type are hypothesis-generating; leaves open optimal models for clinical RV failure research.
PICO
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Population
94 rats subjected to pulmonary artery banding, monocrotaline-induced pulmonary hypertension, aortocaval shunt, or combined models, evaluated at 4 weeks.
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Intervention / Comparator
Different types of right ventricular loading (PAB, PH, shunt, PH + shunt) vs Comparisons between different loading models
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Primary Outcome
Hemodynamics, exercise, and hypertrophy
Cite This Study
Borgdorff et al. (2013) studied Right ventricular failure and abnormal loading (n=94). Different types of right ventricular loading (PAB, PH, shunt, PH + shunt) vs. Comparisons between different loading models was evaluated on Hemodynamics, exercise, and hypertrophy. Different types of right ventricular loading resulted in distinct patterns of RV adaptation, with pulmonary artery banding causing the strongest contractility enhancement and diastolic dysfunction.