September 1, 2018Pulmonary CirculationOpen Access

Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation

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Population

Monocrotaline (MCT) rat model of pulmonary arterial hypertension (PAH)

Design

Preclinical

Follow-up

4 weeks

Authors

DVDaniela Vélez‐RendónUniversity of Illinois Chicago XZXiaoyan ZhangChinese Academy of Medical Sciences & Peking Union Medical College JGJesse W. GerringerMarquette University

Discussion

Member takes

Implication

Hypothesis-generating for early RV remodeling in PAH; leaves open translation beyond animal models.

Structured PICO

Population

Monocrotaline (MCT) rat model of pulmonary arterial hypertension (PAH)

Intervention

Monocrotaline (MCT) exposure

Outcome

Time course of right ventricular early remodeling, morphology, and function (contractility and chamber stiffness)surrogate

In a rat model of pulmonary arterial hypertension, early preservation of stroke volume despite elevated pulmonary pressures is driven by geometric remodeling and increased myocardial contractility.

Cite This Study

Vélez‐Rendón et al. (2018) studied this question.

synapsesocial.com/papers/6a7ab97bf8c4f08607028bfd https://doi.org/10.1177/2045894018800439

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Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider