May 27, 2006AJP Heart and Circulatory Physiology

Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat

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Population

44 rats

Comparison

Monocrotaline at 30 mg/kg body wt or 80 mg/kg… vs Saline-treated control rats

Design

Preclinical

Follow-up

4 weeks

Authors

MHMarleen HesselLeiden University Medical Center PSPaul SteendijkHeart Failure & Transplant BABrigit den AdelLeiden University Medical Center

Discussion

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Implication

MCT rat model produces graded RV hypertrophy and dysfunction; leaves open translation to human PH.

Structured PICO

Population

44 rats (n=15 treated with 30 mg/kg monocrotaline, n=16 treated with 80 mg/kg monocrotaline, n=13 saline-treated controls)

Intervention

Monocrotaline (MCT) at 30 mg/kg body wt (MCT30) or 80 mg/kg body wt (MCT80)

Comparator

Saline-treated control rats

Outcome

Hemodynamics, systolic and diastolic right ventricular (RV) function, and structural changes (RV hypertrophy)surrogate

In a rat model, monocrotaline-induced pulmonary hypertension causes dose-dependent right ventricular hypertrophy and dilation with reduced ejection fraction, even before overt failure.

Cite This Study

Hessel et al. (2006) studied this question.

synapsesocial.com/papers/6a712ac3fe4101aa97e076cd https://doi.org/10.1152/ajpheart.00369.2006

View Full Paper

Ask AI

Bookmark

Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider