Why the study?
Does monocrotaline-induced pulmonary hypertension cause left ventricular dysfunction in Wistar rats?
Does monocrotaline-induced pulmonary hypertension cause left ventricular dysfunction in Wistar rats?
Monocrotaline-induced pulmonary hypertension leads to early molecular changes and stress-induced LV diastolic dysfunction before the onset of baseline LV dysfunction.
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May signal early LV changes in severe PH models; leaves open clinical relevance pending human studies.
Correia‐Pinto et al. (2009) studied this question.
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