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October 9, 2025Circulation Research

Abstract Wed020: Controlled Rigth Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy

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Authors

MPMatteo PonzoniLZLibo ZhangJZJennifer J. Zhang

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Overview

This study demonstrates that pulmonary artery banding improves left ventricular function and promotes biventricular adaptive hypertrophy in a rat model of dilated cardiomyopathy.

Key Points

  • Left ventricular dysfunction was rescued following pulmonary artery banding, resulting in improved ejection fraction.
  • Positive remodeling was observed in treated rats, with significant decreases in end-diastolic volume and LV fibrosis.
  • Histological analysis revealed increased cardiomyocyte diameter and neoangiogenesis, highlighting structural adaptations.
  • Preserved phospholamban phosphorylation in treated rats suggests enhanced calcium cycling and contractility sustainability.

Cite This Study

Ponzoni et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fc0bhttps://doi.org/10.1161/res.137.suppl_1.wed020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Right and left ventricular function after chronic pulmonary artery banding in rats assessed with biventricular pressure-volume loops2006 · 124 citations
  2. 2Late left ventricular myocardial remodeling after pulmonary artery banding for end-stage dilated cardiomyopathy in infants: an imaging study2023 · 8 citations
  3. 3Distinct right ventricle remodeling in response to pressure overload in the rat2016 · 41 citations
  4. 4Reversal of right ventricular pressure loading improves biventricular function independent of fibrosis in a rabbit model of pulmonary artery banding2022 · 10 citations
  5. 5Pulmonary arterial banding in mice may be a suitable model for studies on ventricular mechanics in pediatric pulmonary arterial hypertension2021 · 7 citations