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May 23, 2023International Journal of CardiologyOpen Access

LVEF normalized from a median of 20% at baseline to 56% at 120 days after PAB, with LV end-diastolic volume decreasing from 146 ml/m2 to 48 ml/m2.

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Why the study?

Understanding macroscopic biventricular changes after pulmonary artery banding in children with DCM is needed to investigate the regenerative potential of the myocardium.

Does pulmonary artery banding improve left ventricular remodeling and function in infants with end-stage dilated cardiomyopathy?

Population

7 patients with DCM who positively responded to PAB (out of 9 enrolled)

Comparison

Surveillance after PAB with echocardiography and CMRI

Design

Prospective single-center cohort study

Follow-up

Median of 1.5 years

Authors

MPMatteo PonzoniLZLuca ZanellaERElena Reffo

Discussion

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Member takes

Overview

PAB may promote phased LV recovery in select infant DCM; leaves open durability, fibrosis impact, and need for larger trials.

Structured PICO

Does pulmonary artery banding improve left ventricular remodeling and function in infants with end-stage dilated cardiomyopathy?

P
Population
7 infants with dilated cardiomyopathy (DCM) who positively responded to pulmonary artery banding (out of 9 prospectively enrolled patients)
I
Intervention
Pulmonary artery banding (PAB)
O
Outcome
Left ventricular (LV) rehabilitation/remodeling (LVEF and LV end-diastolic volume) assessed by echocardiography and CMRIsurrogate

Pulmonary artery banding in infant responders with dilated cardiomyopathy promotes significant left ventricular reverse remodeling and normalization of contractility by 4 months, sustained up to 1.5 years.

Cite This Study

Ponzoni et al. (2023) studied this question.

synapsesocial.com/papers/6a8cffdf8a9f77207c301f43https://doi.org/10.1016/j.ijcard.2023.05.040
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prophylactic Pulmonary Artery Banding in Pediatric Dilated Cardiomyopathy: An Additional Therapeutic Option2024 · 3 citations
  2. 2Pulmonary artery banding in infants and young children with end-stage left ventricular dilated cardiomyopathy-Cohort Study2024 · 1 citations
  3. 3Abstract Wed020: Controlled Rigth Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy2025
  4. 4Pulmonary artery banding in pediatric dilated cardiomyopathy: A systematic review and meta-analysis of clinical outcomes and ventricular remodeling2026
  5. 5Pulmonary artery banding to treat end-stage heart failure in infants and young children: A multicenter study2024 · 5 citations