Key result
Pulmonary artery banding in young rats induced right ventricular hypertrophy associated with up-regulation of HSP-27 (up to 3.5-fold), desmin (1.4-fold), and alpha-B-crystallin (1.3-fold).
In a rat model of pulmonary artery banding, right ventricular hypertrophy is associated with a metabolic shift toward glucose utilization and up-regulation of stress response proteins like HSP-27, which correlates with the degree of hypertrophy.
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Rat model data warrant no clinical action; leaves open whether stress proteins drive or mark RV remodeling in pulmonary hypertension.
Faber et al. (2005) studied Right ventricular hypertrophy. Pulmonary artery banding (PAB) was evaluated on Proteomic changes in the pressure overloaded right ventricle. Pulmonary artery banding in young rats induced right ventricular hypertrophy associated with up-regulation of HSP-27 (up to 3.5-fold), desmin (1.4-fold), and alpha-B-crystallin (1.3-fold).
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