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In 2015 the existence of a 'Glymphatic' system in the brain was proposed and further confirmed by subsequent studies. This system is supposed to drain brain waste metabolites particularly during sleep, when it has been shown to increase its activity by about 90%. This system may slow its activity with advancing years; furthermore, in patients with sleep disturbance or Obstructive Sleep Apnoea (OSA) it could be significantly reduced.
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Davide et al. (2024) studied this question.
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