Why the study?
Chronic stress exacerbates cardiovascular disease, but the mechanisms by which stress-responsive brain regions integrate autonomic and endocrine stress responses remain unclear.
Key points are not available for this paper at this time.
Design
Review
No immediate clinical implications; leaves open the neural circuits linking stress integration to cardiovascular risk.
The prevalence and severity of cardiovascular disease (CVD) are exacerbated by chronic stress exposure. While stress-induced sympathetic activity and elevated glucocorticoid secretion impair cardiovascular health, the mechanisms by which stress-responsive brain regions integrate autonomic and endocrine stress responses remain unclear. This review covers emerging literature on how specific cortical and hypothalamic nuclei regulate cardiovascular and neuroendocrine stress responses. We will also discuss the current understanding of the cellular and circuit mechanisms mediating physiological stress responses. Altogether, the reviewed literature highlights the current state of stress integration research, as well unanswered questions about the brain basis of CVD risk.
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Schaeuble et al. (2022) studied this question.