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December 23, 2017SLEEP

Cortical autonomic network gray matter and sympathetic nerve activity in obstructive sleep apnea

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Why the study?

Does moderate-to-severe obstructive sleep apnea induce structural changes in the cortical autonomic network that relate to sympathetic nerve activity?

Population

41 participants, including those with no or mild OSA and moderate-to-severe OSA.

Design

Cross-sectional

Authors

KTKeri S. TaylorPMPhilip J. MillarHMHisayoshi Murai

Discussion

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Overview

Cortical autonomic remodeling in OSA was associated with sympathetic overactivity; hypothesis-generating and requires longitudinal studies before clinical implications.

Structured PICO

Does moderate-to-severe obstructive sleep apnea induce structural changes in the cortical autonomic network that relate to sympathetic nerve activity?

P
Population
41 participants, including those with no or mild OSA (n = 19; 59 ± 2 years; six females; AHI 7 ± 1 events per hour) and moderate-to-severe OSA (n = 22; 59 ± 2 years; five females; AHI 31 ± 4 events per hour).
C
Comparator
No or mild OSA
O
Outcome
Cortical thickness and volume in the insula and cingulate (measured by cortical thickness analysis [CTA] and voxel-based morphometry [VBM]), and their relationship with oxygen desaturation index (ODI) and muscle sympathetic nerve activity (MSNA) burst incidence (BI)surrogate

In obstructive sleep apnea, structural changes in the cortical autonomic network, specifically cingulate and thalamic thickening, are directly related to the intensity of sympathetic discharge during wakefulness.

Cite This Study

Taylor et al. (2017) studied this question.

synapsesocial.com/papers/6a1e860940bc8a3dd76903c8https://doi.org/10.1093/sleep/zsx208
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