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Periodontal diseases, such as gingivitis and periodontitis, are inflammatory disorders that impact the tissues supporting the teeth. These diseases are initiated by bacterial plaque biofilms that form on the tooth surface. The host's immune response to this bacterial challenge plays a crucial role in disease progression. Among the various components of the immune system, antimicrobial peptides (AMPs) such as defensins have gained significant attention for their role in maintaining oral health and their potential therapeutic applications in periodontics. This review article explores the biology, function, and therapeutic potential of defensins in periodontal health and disease.
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Parag et al. (2024) studied this question.
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