Population
78 cases of biopsy-proven renal conditions
Design
Cross-sectional
Authors
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Hypertension independently shapes renal ACE/ACE2 balance; hypothesis-generating for local RAS counterregulation and requires prospective validation before clinical relevance.
Hypertension is independently associated with a higher ACE to ACE2 ratio in human renal tissue, suggesting ACE2 plays a counterregulatory role in the local renin-angiotensin system.
Wakahara et al. (2007) studied this question.
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