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5-Lipoxygenase (5LO) catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (5-HPETE), and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A 4 , LTA 4 ). Thus, 5LO has a central role in leukotriene biosynthesis. This article covers some basic properties of 5LO. Studies regarding the 5LO gene and targeted gene disruption, and 5LO intracellular compartmentalization, are described in other parts of this supplement.
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Olof Rådmark (2000) studied this question.
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