Why the study?
Concerns have emerged from recent studies reporting statin cardiotoxicity and elevated biomarkers of myocardial damage, warranting a detailed discussion of potential mechanisms and future research directions.
Do statins cause cardiotoxicity in patients taking them for cardiovascular disease prevention?
Do statins cause cardiotoxicity in patients taking them for cardiovascular disease prevention?
This review highlights emerging concerns regarding potential statin-induced cardiotoxicity, evidenced by elevated highly sensitive cardiac troponins, and calls for further research into its mechanisms.
No change to statin use for prevention warranted; leaves open prospective validation of troponin elevations as cardiotoxicity signal.
According to current views, statins have a wide range of beneficial effects (lipid and non-lipid) on the cardiovascular system, so they are one of the most commonly used drugs for the prevention and management of patients with cardiovascular diseases. However, it is important to note that information about many beneficial effects of statins is contradictory. In addition, a number of side effects of statins, in particular, myotoxicity, hepatotoxicity, diabetogenic property, etc., may limit the possibility of using statins or even force doctors to cancel these drugs. Also, some concerns are caused by recent studies reporting cardiotoxicity of statins and increased serum concentrations of biomarkers of myocardial damage (highly sensitive cardiac troponins (hs-cTns)) in patients taking statins. This article discusses in detail the possible mechanisms of cardiotoxicity of statins and outlines the directions for further research in this area.
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Aleksey M. Chaulin (2023) studied this question.
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