Why the study?
Cardiac troponin I concentration stability during dialysis has not been fully elucidated.
Does a single dialysis session using low-flux or high-flux membranes affect plasma concentrations of cardiac troponin I in anuric adult patients on chronic hemodialysis?
Does a single dialysis session using low-flux or high-flux membranes affect plasma concentrations of cardiac troponin I in anuric adult patients on chronic hemodialysis?
Dialysis with low-flux membranes, but not high-flux membranes, may artificially increase plasma cardiac troponin I levels, which should be considered when interpreting troponin values in hemodialysis patients.
May artifactually elevate cTnI after low-flux dialysis; leaves open effects on troponin interpretation in hemodialysis.
Aim: Cardiac troponin I (cTnI) concentration stability during dialysis have not been fully elucidated. The aim is to evaluate the effect of a single dialysis session on plasma cTnI. Patients & methods: From 122 consecutive anuric adult patients (75 [61.5%] men, age 27–86 years, median 67) on chronic hemodialysis blood samples for cTnI measurement were taken before and after a dialysis. Results: Dialysis had no effect on high-flux membranes (geometric means ratio = 0.99, 0.94–1.05, df 119, t = -0.19, multiplicity adjusted p = 0.847), but cTnI levels were higher after dialysis in patients on low-flux membranes (geometric means ratio = 1.14, 1.02–1.27, df 119, t = 2.59, adjusted p = 0.021). Conclusion: Dialysis session using low-flux membranes might increase the plasma cTnI.
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Šavuk et al. (2021) studied this question.
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