General multimodal elastic registration based on mutual information

Recent studies indicate that maximizing the mutual information of the joint histogram of two images is an accurate and robust way to rigidly register two mono- or multimodal images. Using mutual information for registration directly in a local manner is often not admissible owing to the weakened statistical power of the local histogram compared to a global one. We propose to use a global joint histogram based on optimized mutual information combined with a local registration measure to enable local elastic registration.