Why the study?
Data were limited regarding the physiological mechanisms of potential sex differences in central hemodynamics and vascular function in chronic kidney disease.
Are there sex differences in central hemodynamics and microvascular function in older patients with nondialysis CKD?
Are there sex differences in central hemodynamics and microvascular function in older patients with nondialysis CKD?
Older female patients with nondialysis CKD exhibit worse central hemodynamics and microvascular function compared to males, partly driven by oxidative stress.
Answers are grounded in this paper and cite their sources.
May warrant closer vascular monitoring in older female nondialysis CKD patients; hypothesis-generating for sex-specific oxidative stress interventions.
There are limited data regarding the physiological mechanisms of potential sex differences in central hemodynamics and vascular function in chronic kidney disease (CKD). We report that older female patients with nondialysis CKD have higher central pulse pressures compared with male patients with CKD. In addition, older females with CKD have lower microvascular function compared with their male counterparts, and oxidative stress contributes to the lower microvascular function in older female patients with CKD.
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Kirkman et al. (2022) studied this question.
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