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December 1, 2021Journal of Personalized MedicineOpen Access

The adjusted odds ratio for C0 for the risk of type 2 diabetes was 0.986 (95% CI: 0.977, 0.994), and C0 showed significant negative correlations with HbA1c (r = -0.438, p < 0.001) and fasting plasma glucose (r = -0.358, p < 0.001).

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Why the study?

This study aimed to establish the validity of carrying out harmonic analysis on synchronous peripheral volume pulses for predicting diabetes-induced subtle changes in heart energy.

Can harmonic analysis of synchronous peripheral volume pulses predict the risk of type 2 diabetes?

Population

141 subjects including 63 healthy elderly subjects and 78 diabetic subjects enrolled at the same hospital

Comparison

Healthy elderly subjects vs diabetic subjects

Design

Proof-of-concept study

Authors

HWHsien–Tsai WuBHBagus HaryadiJCJian-Jung Chen

Discussion

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Overview

C0 was associated with lower T2D odds and glycemic markers; hypothesis-generating for noninvasive prediction, needing prospective validation.

Structured PICO

Can harmonic analysis of synchronous peripheral volume pulses predict the risk of type 2 diabetes?

P
Population
141 subjects (63 healthy elderly subjects and 78 diabetic subjects) enrolled at a single hospital.
I
Intervention
Harmonic analysis (HA) of synchronous peripheral volume pulses using electrocardiogram (ECG) and photoplethysmography (PPG)
C
Comparator
Healthy elderly subjects vs. diabetic subjects
O
Outcome
Association of averaged total pulse energy (C0) with the risk of type 2 diabetes and correlation with diabetes risk factors (HbA1c, fasting plasma glucose)surrogate

Harmonic analysis of peripheral volume pulses, specifically the C0 parameter, may serve as a prognostic indicator for predicting type 2 diabetes.

Cite This Study

Wu et al. (2021) studied this question.

synapsesocial.com/papers/6a1e97cf44dc0a902547db42https://doi.org/10.3390/jpm11121263
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