The triglyceride glucose (TyG) index is associated with decreased myocardial mechano‐energetic efficiency in individuals with different glucose tolerance status

Figures

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  FIGURE 1. Association between insulin‐stimulated myocardial glucose metabolic rate (MrGlu) and TyG index (panel A) or HOMA‐IR index (panel B). MrGlu has been assessed by a 18F‐FDG PET scan combined with euglycemic hyperinsulinemic clamp in 46 subjects with different conditions of glucose intolerance. The triglyceride glucose (TyG) index was calculated as the Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. The homeostasis model assessment index of insulin resistance (HOMA‐IR) was defined as fasting insulin (microU/L) × fasting glucose (mg/dL)/22.5. r = Pearson correlation coefficient.

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  FIGURE 2. ROC curves comparing the accuracy of the TyG index and the HOMA‐IR index in identifying cardiac insulin resistance. The accuracy of each index is assessed using the area under the curve (AUC), which quantifies the overall diagnostic performance. A higher AUC value indicates a better ability to discriminate between individuals with and without cardiac insulin resistance in sample 1. HOMA‐IR, homeostasis model of insulin resistance; ROC, receiver operating characteristic; TyG, triglyceride‐glucose.

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  FIGURE 3. Myocardial MEEi values of the study population stratified according to TyG index quartiles. Myocardial MEEi has been calculated as the ratio between stroke work and myocardial oxygen consumption, while the TyG index was calculated as the Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2] in 1280 subjects included in Sample 2. Quartile 1: TyG values range from 6.66 to 8.22, quartile 2: TyG values range from 8.23 to 8.59, quartile 3: TyG values range from 8.60 to 8.93, quartile 4: TyG values range from 8.93 to 10.87. MEEi, mechano‐energetic efficiency per gram of left ventricular mass; TyG, triglyceride‐glucose. p‐value, comparison among groups.