Key result
Highest triglyceride glucose index links to ~43% greater myocardial ischemia risk in mild-to-moderate CAD.
Why the study?
The association between the TyG index and the incidence of myocardial ischemia in patients with minimal to moderate CAD has not been clearly assessed.
Does a higher triglyceride glucose (TyG) index associate with an increased risk of myocardial ischemia in patients with minimal to moderate coronary artery disease?
Cross-Sectional (n=1,697)
No
Does a higher triglyceride glucose (TyG) index associate with an increased risk of myocardial ischemia in patients with minimal to moderate coronary artery disease?
Odds Ratio: 1.43 (95% CI 1.01–2.04)
Absolute Event Rate: 21.1% vs 15.9%
p-value: p=0.047
An elevated triglyceride glucose index is independently associated with a higher risk of lesion-specific myocardial ischemia detected by CT-FFR in patients with non-obstructive coronary artery disease.
TyG index may flag ischemia risk in minimal-moderate CAD; hypothesis-generating, needs prospective validation before clinical use.
The triglyceride glucose (TyG) index has been suggested as a reliable substitute to indicate insulin resistance. Several studies have identified the association between the TyG index and cardiovascular disease. However, the association between the TyG index and the incidence of myocardial ischemia in patients with minimal to moderate coronary artery disease (CAD) has not been clearly assessed. We aimed to investigate the association between the TyG index and the incidence of myocardial ischemia in patients with minimal to moderate CAD. A total of 1,697 patients who underwent coronary computed tomography angiography (CTA) examinations and had minimal to moderate CAD were retrospectively included in the study. The TyG index and computed tomography-derived fractional flow reserve (CT-FFR) were used to assess insulin resistance (IR) and myocardial ischemia, respectively. Myocardial ischemia was defined as a CT-FFR value ≤ 0.80. Logistic regression models were used to explore the associations between the TyG index and myocardial ischemia. The incidence of myocardial ischemia was higher in the highest TyG index tertile (T3) group than in the lowest TyG index tertile (T1) group. After adjusting for other variables, the T3 group remained associated with a higher risk of myocardial ischemia than the T1 group did (OR, 1.43; 95% CI, 1.01-2.04; p = 0.047). A 1- standard deviation (SD) increase in the TyG index was correlated with a 19-24% elevated risk of myocardial ischemia when regarding the TyG index was considered as a continuous variable. Subgroup analysis revealed similar effects. A TyG index is associated with a higher risk of myocardial ischemia detected by CT-FFR in patients with minimal to moderate CAD.
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Huang et al. (2024) conducted a cross-sectional in Minimal to moderate coronary artery disease (n=1,697). Triglyceride glucose (TyG) index vs. Lowest TyG index tertile (T1 group) was evaluated on Myocardial ischemia (CT-FFR ≤ 0.80) (OR 1.43, 95% CI 1.01-2.04, p=0.047). The highest tertile of the triglyceride glucose index was associated with a significantly higher risk of myocardial ischemia (OR 1.43) compared to the lowest tertile in patients with minimal to moderate coronary artery disease.
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