A 29-year-old man with vitiligo was treated by sympathectomy and later by racemized α-melanin-stimulating hormone (MSH). Only a slight increase in melanogenic activity of normal skin followed sympathectomy, while the vitiligo progressed. Alpha-MSH produced darkening and melanocytic activity in normal skin, but vitiliginous areas were unaffected.
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Aaron B. Lerner (1966) studied this question.
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