Why the study?
Does endothelial NO synthase overexpression inhibit atherosclerotic lesion formation in apoE-deficient mice?
Does endothelial NO synthase overexpression inhibit atherosclerotic lesion formation in apoE-deficient mice?
Chronic overexpression of eNOS accelerates rather than inhibits atherosclerosis in hypercholesterolemic mice, likely due to eNOS dysfunction.
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Challenges assumption that eNOS augmentation inhibits atherosclerosis; leaves open clinical relevance in hypercholesterolemic patients.
Ozaki et al. (2002) studied this question.
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