This review discusses factors regulating renal haemodynamics in spontaneously hypertensive rats and their link to hypertension pathophysiology.
Preclinical synthesis of renal hemodynamic factors in hypertensive rats; leaves open translation to human hypertension management.
Hypertension is one of the leading causes of health morbidity and mortality which are linked to many life threatening diseases such as stroke heart problems and renal dysfunction. The integrity of renal microcirculation is crucial to maintaining the clearance and the excretory function in the normotensive and hypertensive conditions. Furthermore, any alteration in the renal function is involved in the pathophysiology of hypertension. The aim of this review is to provide a brief discussion of some factors that regulate renal haemodynamics in spontaneously hypertensive rats, an animal model of hypertension, and how these factors are linked to the disease.
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Ahmeda et al. (2015) studied this question.
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