Key result
A 2-hour infusion of GLP-1 in healthy men significantly increased cardiac output, subcutaneous abdominal adipose tissue blood flow, and leg blood flow compared with saline.
Why the study?
Does GLP-1 infusion elicit vasodilation in adipose tissue, skeletal muscle, and splanchnic tissues in healthy men?
RCT (n=9)
random order
Does GLP-1 infusion elicit vasodilation in adipose tissue, skeletal muscle, and splanchnic tissues in healthy men?
Acute GLP-1 administration increases cardiac output and elicits vasodilation in adipose tissue and skeletal muscle in healthy men.
Acute GLP-1 effects on cardiac output and tissue perfusion merit evaluation in patients; extends mechanistic evidence for GLP-1 receptor agonism.
In healthy subjects, we recently demonstrated that during acute administration of GLP ‐1, cardiac output increased significantly, whereas renal blood flow remained constant. We therefore hypothesize that GLP ‐1 induces vasodilation in other organs, for example, adipose tissue, skeletal muscle, and/or splanchnic tissues. Nine healthy men were examined twice in random order during a 2‐hour infusion of either GLP ‐1 (1.5 pmol kg −1 min −1 ) or saline. Cardiac output was continuously estimated noninvasively concomitantly with measurement of intra‐arterial blood pressure. Subcutaneous, abdominal adipose tissue blood flow ( ATBF ) was measured by the 133 Xenon clearance technique. Leg and splanchnic blood flow were measured by Fick's Principle, using indocyanine green as indicator. In the GLP ‐1 study, cardiac output increased significantly together with a significant increase in arterial pulse pressure and heart rate compared with the saline study. Subcutaneous, abdominal ATBF and leg blood flow increased significantly during the GLP ‐1 infusion compared with saline, whereas splanchnic blood flow response did not differ between the studies. We conclude that in healthy subjects, GLP ‐1 increases cardiac output acutely due to a GLP ‐1‐induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.
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Asmar et al. (2017) conducted an RCT in Healthy (n=9). GLP-1 vs. saline was evaluated on Cardiac output, adipose tissue blood flow, leg and splanchnic blood flow. A 2-hour infusion of GLP-1 in healthy men significantly increased cardiac output, subcutaneous abdominal adipose tissue blood flow, and leg blood flow compared with saline.
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