Key result
In rats with experimental glomerulonephritis, single nephron filtration rates were highly heterogeneous but maintained almost complete glomerulotubular balance, with mean SNGFR significantly reduced in acute anti-GBM nephritis compared to controls.
Population
Male Wistar rats
Comparison
Induction of autologous immune complex nephritis… vs Control rats receiving complete Freund's…
Design
Preclinical
Follow-up
5-20 months for AICN, 10-38 days for anti-GBM
Authors
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Rat models show resilient glomerulotubular balance amid filtration heterogeneity; leaves open translation to human glomerulonephritis.
Absolute Event Rate: 19.4% vs 40.6%
p-value: p=<0.001
Experimental models of glomerulonephritis demonstrate marked heterogeneity in single nephron function while maintaining glomerulotubular balance despite severe architectural derangement.
Allison et al. (1974) studied Experimental Glomerulonephritis (n=77). Induction of autologous immune complex nephritis (AICN) or anti-GBM nephritis vs. Control rats (CFA alone or no injection) was evaluated on Single nephron glomerular filtration rate (SNGFR) (p=<0.001). In rats with experimental glomerulonephritis, single nephron filtration rates were highly heterogeneous but maintained almost complete glomerulotubular balance, with mean SNGFR significantly reduced in acute anti-GBM nephritis compared to controls.
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