An exploration of ocular glucose levels with flexible RF biosensor using polyethylene terephthalate

This paper presents a minimally invasive, flexible and disposable RF Biosensor used for the detection of Ocular glucose level, employed with the RF resonator analyzed at 4.30 GHz. Linear relationship between glucose concentration in the tear and resonance frequency was obtained in a range of 1-7mg/dl. The new sensor was optimized to achieve very low detection limit of 0.25 mg/dl, which is required to monitor glucose levels in the tear fluid with a sensitivity of 12 MHz/dl. Thus, a considerably lower shift in the resonance frequency was obtained with a maximum and minimum shift of 362 and 60 MHz for the maximum and minimum concentration of 7 mg/dl and 1 mg/dl ocular glucose level, respectively.