Key result
The concentration of doxorubicin decreases exponentially with distance from tumor blood vessels, dropping to half its perivascular concentration at 40 to 50 µm.
Population
Murine 16C and EMT6 tumors and human prostate cancer PC-3 xenografts in mice
Design
Preclinical
Authors
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May limit doxorubicin efficacy via poor tumor penetration; leaves open whether vascular strategies improve delivery.
Doxorubicin has limited distribution in solid tumors, decreasing exponentially with distance from blood vessels, which may contribute to clinical resistance.
Primeau et al. (2005) studied Solid tumors. Doxorubicin was evaluated on Distribution of doxorubicin in relation to blood vessels and regions of hypoxia. The concentration of doxorubicin decreases exponentially with distance from tumor blood vessels, dropping to half its perivascular concentration at 40 to 50 µm.
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