Key result
Parathyroidectomy linked to normalized Tp-e intervals and ratios in primary hyperparathyroidism.
Why the study?
This study aimed to evaluate new ventricular repolarization parameters (Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio) in patients with primary hyperparathyroidism and investigate the potential effect of parathyroidectomy on these markers.
Does parathyroidectomy improve ventricular repolarization parameters (Tp-e interval, Tp-e/QT, Tp-e/QTc) in patients with primary hyperparathyroidism?
Observational (n=52)
Single-blind
No
Does parathyroidectomy improve ventricular repolarization parameters (Tp-e interval, Tp-e/QT, Tp-e/QTc) in patients with primary hyperparathyroidism?
Absolute Event Rate: 84.1% vs 92.7%
p-value: p=<0.001
Parathyroidectomy in patients with primary hyperparathyroidism significantly improves surrogate ECG markers of ventricular arrhythmia (Tp-e interval and ratios), suggesting a potential reduction in sudden cardiac death risk.
May support arrhythmic risk reduction after parathyroidectomy in primary hyperparathyroidism; leaves open confirmation in outcome trials.
Aims: This study aimed to evaluate Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratios, which are new ventricular repolarization (VR) parameters in primary hyperparathyroidism (PHPT) patients, and also investigate the potential effect of parathyroidectomy (PTx) on these parameters. Methods: In total, 27 patients with PHPT who underwent PTx and 25 control subjects were selected for our study. Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratios of patients planned for PTx were compared to healthy matched controls. Electrocardiographic parameters measured 6 months after the surgery were also compared with preoperative values for each patient. Results: Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio were significantly higher in PHPT patients compared to the control group (p<0.001, for all).It was observed that the parameters mentioned after surgery decreased significantly, and there was no statistical difference when compared to the control group.The correlation analysis revealed a significant and positive correlation between corrected calcium (CCa) and PTH levels with Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio (for Ca; r=0.515, p=0.006; r=0.398, p=0.040; r=0.797, p<0.001 respectively vs. for PTH; r=538, p=0.04; r=0.422, p=0.028; r=0.812, p<0.001 respectively). Conclusions: This study showed that Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were prolonged in PHPT.These values, which are accepted as an indicator of sudden cardiac death after PTx, decreased significantly. In addition, both high PTH and high calcium(Ca) levels appear to have the potential to cause arrhythmogenic effects separately.
No takes yet. Share an insight, caveat, or question.
Çetınkaya et al. (2024) conducted an observational in Primary hyperparathyroidism (n=52). Parathyroidectomy vs. Preoperative baseline was evaluated on Tp-e interval (ms) (p=<0.001). Parathyroidectomy significantly reduced the prolonged Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios in patients with primary hyperparathyroidism, returning them to levels comparable to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: