An Unusual Case of Acquired AGK-BRAF Gene Fusion in Metastatic EGFR-mutant Lung Adenocarcinoma: A Case Report

This case report describes a 60-year-old male patient initially diagnosed with metastatic lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) exon 21 L858R mutation who subsequently developed a rare acquired AGK-BRAF fusion during the course of treatment. This case highlights the complexity of managing EGFR-mutant lung cancer with additional acquired genetic alterations, the potential role of these alterations in treatment resistance, and the importance of comprehensive genomic profiling in guiding personalized treatment strategies.