A Case of Lung Adenocarcinoma With Concurrent EGFR Mutation and ALK Fusion Combined With Literature Review

Q: What type of study is this?

This is a Literature Review study.

Y J Chen; Fei Qi; Yi‐Xin Zeng; Jingwen Tan; Mingming Hu; Hongmei Zhang; Tongmei Zhang

doi:10.1002/ccr3.71749

January 1, 2026Clinical Case ReportsOpen Access

A Case of Lung Adenocarcinoma With Concurrent EGFR Mutation and ALK Fusion Combined With Literature Review

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Key Points

The study aims to highlight the importance of identifying co-alterations in lung adenocarcinoma patients experiencing rapid progression on therapy.
Analyzed a case of lung adenocarcinoma with concurrent EGFR mutation and ALK fusion.
Reviewed literature on co-alterations and their impact on treatment outcomes.
Assessed the response to alectinib after identification of resistant mechanisms.
Identification of EML4‐ALK fusion as a resistant mechanism in EGFR‐mutant lung adenocarcinoma.
Switching to alectinib resulted in rapid and sustained clinical improvement.

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Implication

This case demonstrates rapid clinical improvement after switching to alectinib for resistant mechanisms in EGFR-mutant lung adenocarcinoma.

Abstract

This case underscores the critical importance of retesting for resistant mechanisms, such as EML4‐ALK fusion, in patients with EGFR‐mutant lung adenocarcinoma who experience rapid progression on EGFR‐tyrosine kinase inhibitor (TKI) therapy. Early identification of such co‐alterations and an immediate switch to alectinib can lead to rapid and sustained clinical improvement.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/695d856e3483e917927a51c3 https://doi.org/10.1002/ccr3.71749

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A Case of Lung Adenocarcinoma With Concurrent EGFR Mutation and ALK Fusion Combined With Literature Review

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A Case of Lung Adenocarcinoma With Concurrent EGFR Mutation and ALK Fusion Combined With Literature Review

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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