Prognostic Indicators of 4-Week Clinical Improvement withChlordiazepoxide and Hydroxyzine in Anxious NeuroticOutpatients

A multiple regression analysis conducted with 125 anxious outpatients has indicated chlordiazepoxide (40 mg/day) to produce more improvement than hydroxyzine (400 mg/day); and patients from general practice, with better prognoses, and with higher initial anxiety to do better, irrespective of treatment agent, than patients from clinics, with poor prognoses, and with low initial anxiety. Furthermore, the analysis indicated chlordiazepoxide to produce more improvement than hydroxyzine in more chronically ill, more liked, and employed patients, while hydroxyzine was especially effective in less liked and unemployed patients. Several explanations have been offered for these findings.