What question did this study set out to answer?

The aim was to determine if beta-2-adrenergic receptors in coronary vessels are functionally innervated.

June 1, 1976American Journal of Physiology-Legacy Content

Coronary vascular sympathetic beta-receptor innervation

Q: What is the clinical evidence from this study?

Study design: Other. Population: Coronary vascular sympathetic beta-receptor innervation. Intervention: Stellate ganglion stimulation and sequential receptor blockades vs. prestimulation control values. Primary outcome: Coronary blood flow and coronary sinus oxygen tension.

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Key result

Stimulation of the left stellate ganglion after sequential receptor blockades revealed little functional innervation of coronary vascular beta-2 receptors in a dog model.

Why the study?

Are coronary vascular beta-2-vasodilator receptors functionally innervated?

Population

Dog in situ modified Langendorff preparation with constant coronary perfusion pressure, supported with a…

Comparison

Stimulation of the left stellate ganglion with… vs Prestimulation control values.

Design

Preclinical

Authors

HFHamilton Fn EFEO Feigl

Discussion

Member takes

Implication

Questions functional beta-2 innervation in canine coronaries; leaves open human relevance and need for translational studies.

Key Points

The aim was to determine if beta-2-adrenergic receptors in coronary vessels are functionally innervated.
Conducted a modified Langendorff preparation on dogs with constant coronary perfusion pressure.
Used pump oxygenator to support heart and systemic circulation during experiments.
Administered beta-1, alpha, and beta-2 receptor blockers, assessing effects on coronary blood flow and oxygen tension.
Stimulation of the left stellate ganglion increases coronary blood flow and decreases coronary sinus oxygen tension before beta-1 blockade.
Post beta-1 blockade, coronary blood flow decreased, revealing alpha-receptor vasoconstriction.
Minimal increase in flow and oxygen tension was observed after beta-2 blockade, indicating poor functional innervation.

Structured PICO

Are coronary vascular beta-2-vasodilator receptors functionally innervated?

Population

Dog in situ modified Langendorff preparation used to study coronary vascular sympathetic beta-receptor innervation.

Intervention

Stimulation of the left stellate ganglion with sequential pharmacological blockade (practolol 10 mg/kg, Dibozane 5 mg/kg, propranolol 2 mg/kg) and direct intracoronary injections of isoproterenol, norepinephrine, and epinephrine.

Comparator

Prestimulation control values.

Outcome

Coronary blood flow and coronary sinus oxygen tension.surrogate

This preclinical study demonstrates that there is little functional innervation of coronary vascular beta-2 receptors in a dog model.

Cite This Study

Fn et al. (1976) studied Coronary vascular sympathetic beta-receptor innervation. Stellate ganglion stimulation and sequential receptor blockades vs. prestimulation control values was evaluated on Coronary blood flow and coronary sinus oxygen tension. Stimulation of the left stellate ganglion after sequential receptor blockades revealed little functional innervation of coronary vascular beta-2 receptors in a dog model.

synapsesocial.com/papers/6a1eb2e4eed4f0c78fa4261b https://doi.org/10.1152/ajplegacy.1976.230.6.1569

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Coronary vascular sympathetic beta-receptor innervation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Coronary vascular sympathetic beta-receptor innervation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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